It may be recommended for people who are more than 30 pounds overweight. In clinical trials, people who took this drug lost an average of 5%-10% of their body weight. It works by making the person feel full and thereby decreases food intake. However, it is most common in people who are over the age of 65. Even unexplained weight loss of less than 5 percent of body weight or 10 pounds may be the sign of a serious condition in older people. Several other studies have monitored overweight people who drank 1-1.5 liters (3450 oz) of water daily for a few weeks.